Studies in BioPharma
Experience
Scientific publications
1. JIMÉNEZ R. Silvia L., CASTAÑO P. Hader I., QUINTANA C. Juan C., CIRO G. Gelmy L., QUINCHÍA B. Lida. ESTRADA G. Sebastián. (2008). Cell suspension establishment of Bixa orellana L., phenolic compound producers with potential antiophidic activity. VITAE 15, 1; pp 70 – 76.
2. ESTRADA G. Sebastián, QUINTANA C. Juan C., JIMÉNEZ R. Silvia L, ALARCON P. Juan C., PEREAÑEZ J. Jaime A., VARGAS Leidy J. (2009). Preliminary phytochemistry assessment of Heliconia psittacorum and Heliconia rostrata and the potential inhibitory activity of some effects of the Bothrops asper (mapaná X) venom. VITAE 16, 2; pp 237 – 244.
3. G. Sebastian ESTRADA, Silvia L. JIMENEZ, P. Juan C. ALARCON, Leidy J. VARGAS. (2010). Application of Ultrasound in the dissolution of potential antiophidian compounds from two ethanolics extracts of two species of Heliconias. Ultrasonics Sonochemistry 17, 5; pp 756 - 759.
4. Maria Dolores Ivorra, N Flacco, S Estrada, M Perez-Aso, P D’Ocon. (2010). G protein-coupled 7TM receptors: from molecular to physiological function role of nitric oxide/cyclic GMP and cyclic amp in the beta-adrenoceptor vasorelaxant response. Basic & Clinical Pharmacology & Toxicology, 107 (Suppl. 1), pp 348.
5. Rafael Otero-Patiño, Álvaro Segura, María Herrera, Yamileth Angulo, Guillermo León, José María Gutiérrez, Jacqueline Barona, Sebastián Estrada, et al (2012). Comparative study of the efficacy and safety of two polyvalent, caprylic acid fractionated [IgG and F(ab0)2] antivenoms, in Bothrops asper bites in Colombia. Toxicon 59 344–355.
6. Sebastian Estrada Gomez, Leidy Vargas Munoz, Alejandro Ramirez, Juan Quintana Castillo. (2012)Milking and Partial Characterization of Pamphobeteus spp (Aranae; Theraphosidae) Venom, from the Colombian Andean Region. Toxicon, Volume 60, Issue 2, August 2012, Pages 231-232
7. N Flacco, V Segura, M Perez-Aso, S Estrada, JF Seller, F Jiménez-Altayó, MA Noguera, P D’Ocon, E Vila and MD Ivorra. (2013). Different b-adrenoceptor subtypes coupling to cAMP or NO/cGMP pathways: implications in the relaxant response of rat conductance and resistance vessels. British Journal of Pharmacology (2013) 169 413–425.
8. Sebastian Estrada-Gomez, Leidy Johana Vargas Muñoz, Juan C. Quintana Castillo. (2013). Extraction and partial characterization of venom from the Colombian spider Pamphobeteus aff. nigricolor(Aranae:Theraphosidae). Toxicon, Volume 76, 15 December 2013, Pages 301-309
9. Sebastián Estrada-Gómez, Juan Carlos Quintana Castillo, Leidy Johana Vargas Muñoz. (2014). Accidente ofídico en animales de pastoreo: acercamiento epidemiológico, clínico y de manejo. Rev. Med. Vet. 27 páginas 13-23
10. Leidy Johana Vargas Munoz, Sebastian Estrada-Gomez, Vitelbina Núnez,Libia Sanz, Juan J. Calvet, (2014). Characterization and cDNA sequence of Bothriechis schlegelii l-aminoacid oxidase with antibacterial activity. International Journal of Biological Macromolecules 69 (2014) 200–207.
11. Sebastián Estrada-Gómez, Nelson Ivan Cupitra, Walter Murillo Arango and Leidy Johana Vargas Muñoz. (2014). Intraspecific Variation of Centruroides edwardsii Venom from Two Regions of Colombia. Toxins, 6, 2082-2096.
12. Leidy Johana Vargas Muñoz and Sebastián Estrada-Gómez. (2014). Purification and Characterization of Venom Components as Source for Antibiotics. Mini-Reviews in Organic Chemistry, 11, 15-27
13. Carlos Perafán, Yeimy Cifuentes & Sebastián Estrada-Gomez. (2015). Aguapanela, a new tarantula genus from the Colombian Andes (Araneae, Theraphosidae). Zootaxa 4033 (4): 529–542.
14. Nelson Iván CUPITRA VERGARA; Sergio CUBIDES CUBILLOS; Mónica María SALDARRIAGA-CORDOBA; Sebastián ESTRADA-GÓMEZ. (2015). Distribución De Centruroides edwardsii (Gervais, 1843) en el Departamento en Antioquia, Colombia. Acta biol. Colomb. 2015;20(1):207-215.
15. Sebastian Estrada-Gomez , Leidy Johana Vargas Muñoz, Paula Lanchero and Cesar Segura Latorre. (2015). Partial Characterization of Venom from the Colombian Spider Phoneutria boliviensis(Aranae:Ctenidae). Toxins 2015, 7, 2872-2887.
16. Leidy Johana Vargas-Muñoz, Sebastián Estrada-Gómez, Julieta Vásquez-Escobar. (2015). Toxinas de venenos de serpientes y escorpiones, una fuente natural de moléculas con actividad antimicrobiana. doi: Revista Curare / Volumen 2 / Número 2 / Julio-Diciembre 2015. http://dx.doi.org/10.16925/cu.v2i2.1166.
17. Yeimy Cifuentes, Sebastián Estrada-Gomez, Leidy Johana Vargas-Muñoz, Carlos Perafán. (2016).Description and molecular characterization of a new species of tarantula, Pamphobeteus verdolaga, from Colombia. (Araneae: Mygalomorphae: Theraphosidae). ZOOLOGIA 33(6): e20160113.
18. Sebastián Estrada-Gómez, Leidy Johana Vargas Munoz, Mónica Saldarriaga-Córdoba, Juan Carlos Quintana Castillo. (2016). Venom from Opisthacanthus elatus scorpion of Colombia, could be more hemolytic and less neurotoxic than thought. Acta Tropica 153 (2016) 70–78.
19. Sebastian Estrada-Gomez, Lyz Gomez-Rave, Leidy Johana Vargas-Munoz, Arie van der Meijden. (2017). Characterizing the biological and biochemical profile of six different scorpion venoms from the Buthidae and Scorpionidae family. Toxicon 130 (2017) 104e115.
20. Juan Carlos Quintana-Castillo, Isabel Cristina Ávila-Gómez, Juan Felipe Ceballos-Ruiz, Leidy Johana Vargas-Muñoz, Sebastián Estrada-Gómez. (2017). Efecto citotóxico de fosfolipasas A2 del veneno de Crotalus durissus cumanensis de Colombia. Revista de Investigación en salud. Volumen 4, Número 1, Enero - Junio 2017, Págs. 16-37.
21. Sebastian Estrada-Gomez, Leidy Johana Vargas-Munoz, Monica Saldarriaga-Cordoba, Yeimy Cifuentes, Carlos Perafan. (2017). Identifying different transcribed proteins in the newly described Theraphosidae Pamphobeteus verdolaga. Toxicon 129 (2017) 81e88.
22. Arie van der Meijden, Bjørn Koch, Tom van der Valk, Leidy J. Vargas‐Muñoz, Sebastian Estrada‐Gómez. (2017). Target-Specificity in Scorpions; Comparing Lethality of Scorpion Venoms across Arthropods and Vertebrates. Toxins 2017, 9, 312; doi: 10.3390/toxins9100312.
23. Juan Carlos Quintana-Castillo, Leidy JohanaVargas, Cesar Segura, Sebastián Estrada-Gómez, Julio César Bueno-Sánchez and Juan Carlos Alarcón. (2018). Characterization of the Venom of C. d. cumanesis of Colombia: Proteomic Analysis and Antivenomic Study. Toxins 2018, 10, 85.
24. Sebastian Estrada-Gomez, Fernanda Caldas Cardoso, Leidy Johana Vargas-Muñoz, Juan Carlos Quintana-Castillo, Claudia Marcela Arenas Gómez, Sandy Steany Pineda and Monica Maria Saldarriaga-Cordoba. (2019). Venomic, Transcriptomic, and Bioactivity Analyses of Pamphobeteus verdolaga Venom Reveal Complex Disulfide-Rich Peptides That Modulate Calcium Channels. Toxins 2019, 11, 496; doi:10.3390/toxins11090496.
25. Juan Carlos Quintana-Castillo, Sebastián Estrada-Gómez, Jaiberth Antonio Cardona-Arias. (2020). Economic Evaluations of Interventions for Snakebites: A Systematic Review. ClinicoEconomics and Outcomes Research 2020:12 547–554.
26. Sebastian Estrada-Gómez, Leidy Johana Vargas-Muñoz, Cesar Segura Latorre, Monica Maria Saldarriaga-Cordoba and Claudia Marcela Arenas-Gómez. (2021). Analysis of High Molecular Mass Compounds from the Spider Pamphobeteus verdolaga Venom Gland. A Transcriptomic and MS ID Approach. Toxins 2021, 13, 453. https://doi.org/10.3390/toxins13070453.
27. Sebastian Estrada-Gómez, Leidy Johana Vargas-Muñoz, Monica Maria Saldarriaga-Córdoba, Arie van der Meijden. (2021). MS/MS analysis of four scorpion venoms from Colombia: a descriptive approach. J Venom Anim Toxins incl Trop Dis, 2021, 27:e20200173.
28. Sebastian Estrada-Gomez, Vitelbina Núñez, Leidy Johana Vargas-Muñoz, Carlos A. Madrid-Bracamonte and Lina Maria Preciado (2021). Characterization of a Lab-Scale Process to Produce Whole IgG Antivenom Covering Scorpion Stings by Genus Tityus and Centruroides of Colombia. Pharmaceuticals 2022, 15, 1047.
29. Sebastián Estrada-Gómez, Leidy Johana Vargas-Muñoz, Luis Felipe Higuita-Gutiérrez (2022). Epidemiology of Snake Bites Linked with the Antivenoms Production in Colombia 2008–2020: Produced Vials Do Not Meet the Needs. Drug, Healthcare and Patient Safety 2022:14 171–184.
30. Cristian Salinas-Restrepo, Elizabeth Misas, Sebastian Estrada-Gómez, Juan Carlos Quintana-Castillo, Fanny Guzman, Juan C. Calderón, Marco A. Giraldo and Cesar Segura (2022). Improving the Annotation of the Venom Gland Transcriptome of Pamphobeteus verdolaga, Prospecting Novel Bioactive Peptides. Toxins 2022, 14, 408.
31. Alejandra Arroyave-Muñoz, Arie van der Meijden, Sebastián Estrada-Gómez, Luis Fernando García (2022). Linking toxicity and predation in a venomous arthropod: the case of Tityus fuhrmanni (Scorpiones: Buthidae), a generalist predator scorpion. J Venom Anim Toxins incl Trop Dis, 2022, 28.
32. Santiago Tabares Vélez, Lina María Preciado, Leidy Johana Vargas Muñoz, Carlos Alberto Madrid Bracamonte, Angelica Zuluaga, Jeisson Gómez Robles, Camila Renjifo-Ibañez and Sebastián Estrada-Gómez (2024). Standard Quality Characteristics and Efficacy of a New Third-Generation Antivenom Developed in Colombia Covering Micrurus spp. Venoms. Toxins 2024, 16, 183.
33. Sebastian Estrada-Gomez, Cristian Salinas-Restrepo, Leidy Johana Vargas-Munoz, Fanny Guzman, Cesar Segura, Davinia Pla, Libia Sanz, Juan J Calvete. (2025). Synthesis of U-theraphotoxin-Pv1a_1, an Aedes aegypti larvicidal disulfide bridged peptide from the Colombian tarantula Pamphobeteus verdolaga (Araneae: Theraphosidae). Toxicon:X 26 (2025) 100224.
34. Mónica Saldarriaga-Córdoba, Claudia Clavero-León, Paola Rey-Suárez, Vitelbina Núñez-Rangel and Sebastián Estrada-Gómez. (2026). In-Depth Multi-Assembler Venom-Gland Transcriptomics of Three Medically Important Colombian Snakes Highlights Diversity of Accessory, Low-Abundance Protein Families. Toxins 2026, 18, 118.
35. Vanessa Cifuentes, Angélica Maria Zuluaga-Cabrera, Leidy Johana Vargas-Muñoz and Sebastián Estrada-Gómez. (2026). Obtention and preliminary clinical evaluation of an equine albumin for intravenous administration in adult Colombian Creole Horses (Equus ferus caballus). PLOS One February 20, 2026.